ADAM33基因多态性与慢性气道疾病相关研究进展

Research progress of correlation between ADAM33 gene single nucleotide polymorphisms and chronic airway disease

ADAM33基因位于第20号染色体短臂上（20p13），是ADAM家族的一个成员。ADAM33基因可以影响多种疾病表型。近期研究发现，ADAM33基因在慢性气道疾病中发挥重要作用；ADAM33在间质细胞限制性表达，参与气道结构的改变，与支气管高反应性和加速肺功能下降有关。目前已经确认ADAM33基因是哮喘的易感基因，而该基因与COPD也有关联。ADAM33基因与不同种族及区域人群慢性气道疾病的相关性成为研究热点。本文以ADAM33的结构功能为基础，从哮喘链接到COPD，对ADAM33基因多态性与慢性气道疾病的相关性作一综述。

ADAM33 gene located on the short arm of chromosome 20 （20p13） ,is a member of the family of ADAM. ADAM33 gene can affect the phenotype of a variety of diseases. Recent studies have found that, ADAM33 gene plays an important role in chronic airway diseases. ADAM33 expresses restrictively in mesenchymal cells, takes part in the change of structural airway, and is associated with bronchial hyperresponsiveness and decreased lung function. ADAM33 genes have been identified asthma susceptibility genes,and the gene is also associated with COPD. The correlation between ADAM33 gene and chronic airway diseases of different racial and area populations has become one of the hot research spots. Here,we based on the structure and function of ADAM33,1ink to COPD from asthma, summarize the correlation ADAM33 gene with chronic airway diseases are reviewed.