化疗在晚期和复发性耐药性子宫内膜癌治疗中的作用

The role of adjuvant chemotherapy in women with advanced or recurrent resistant endometrial cancer

晚期和复发性耐药性子宫内膜癌预后差,化疗在子宫内膜癌治疗中具有越来越重要的价值。新辅助化疗、序贯放化疗、分子靶向药物如贝伐单抗等是目前治疗子宫内膜癌的研究热点,紫杉醇联合卡铂和蒽环类药物联合铂类是一线化疗药物方案。复发性耐药性子宫内膜癌治疗尚无成熟方案,仍需大样本临床试验验证。

The prognosis of advanced or recurrent re- sistant endometfial cancer is poor ,and the role of ad- juvant chemotherapy has become more and more im- portant.There are many new progress focusing on neoadjuvant chemotherapy, sequential muhi-modality adjuvant chemotherapy and radiation, and molecular targeted therapy and so on.Now, paclitaxel combined with earboplatin and anthracycfine plus platinum as first line chemotherapy regimen;however,there have been few studies about drug-resistant endometrial carcinoma, and still more samples are needed for clinical trial studies.