胰腺脂肪酶相关研究进展

The Progress of Research About Pancreatic Lipase

胰腺脂肪酶包括甘油三酯脂酶与其相关蛋白1和2、胆盐刺激性脂酶及磷脂酶A2。这些脂肪酶协调作用,是膳食脂肪消化的主要酶。胰腺脂肪酶的发育不仅与年龄相关,还受到膳食结构、内分泌激素等的调节,其表达的改变与肥胖等代谢性疾病有着密切的关系。胰腺脂肪酶的调节可能是治疗肥胖等代谢性疾病的靶点。

During the digestive procedure,pancreatic lipase is known as the main enzyme in vivo for digestion and absorption of dietary fat,consisting of pancreatic triglyceride lipase,pancreatic lipase related proteins 1 and 2,bile salt- stimulated Lipase and phospholipase A2. The changes of the development pattern of pancreatic lipase have confirmed associations with metabolic diseases such as obesity,not only because age is connected with the development of pancreatic lipase,but also pancreatic lipase itself is regulated by the dietary structure and endocrine hormone.