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补体C1q/肿瘤坏死因子相关蛋白家族研究进展 被引量：20

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摘要 补体C1q/肿瘤坏死因子相关蛋白(complement-C1q/TNF-related protein,CTRP)是新近发现的一个脂肪因子超家族,目前已经发现有15个成员。CTRP家族成员结构与脂联素相似,均包含一个氨基末端的信号肽、一个短的可变结构域、一个胶原样结构域和一个羧基末端的球形结构域。目前研究表明CTRP家族成员参与调控机体诸多生理和病理过程,如糖脂代谢、炎症、软骨发生及发育、心肌保护、血管舒张等。本文将对CTRP家族各成员的组织分布、表达调控及主要生物学功能做一综述。
作者 雷虹 张洁 王瑾瑜 吴立玲
机构地区 北京大学医学部生理学与病理生理学系
出处 《生理科学进展》 CAS CSCD 北大核心 2015年第1期43-48,共6页 Progress in Physiological Sciences
基金 国家基础科学人才培养基金(NFFTBS)J0630853/J0108 教育部博士点专项基金(20120001110009) 国家自然科学基金(81270158)资助课题
关键词 CTRP 代谢 炎症 心血管
分类号 Q291 [生物学—细胞生物学]
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参考文献15

  • 1Seldin MM, Peterson JM, Byerly MS, et al. Myonectin (CTRP15) , a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem, 2012, 287 : 11968 ~ 11980.
  • 2Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al. Mo- lecular, biochemical and functional characterizations of C1 q/ TNF family members: adipose-tissue-selective expression patterns, regulation by PPARy agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J, 2008, 416 : 161 ~ 177.
  • 3Peterson JM, Aja S, Wei Z, et al. CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACE) in- hibition. J Biol Chem, 2012, 287 : 1576 ~ 1587.
  • 4Peterson JM, Seldin MM, Tan SY, et al. CTRP2 overex- pression improves insulin and lipid tolerance in diet-induced obese mice. Plos One, 2014, 9 : e88535.
  • 5Zhou Y, Wang JY, Feng H, et al. Overexpression of clq! tumor necrosis factor-related protein-3 promotes phosphate- induced vascular smooth muscle cell calcification both in vi- vo and in vitro. Arterioscler Thromb Vasc Biol, 2014, 34 : 1002 - 1010.
  • 6Schmid A, Kopp A, Hanses F, et al. Clq/TNF-related pro- tein-3 ( CTRP-3 ) attenuates lipopolysaccharide ( LPS)-in- duced systemic inflammation and adipose tissue Erk-1/-2 phosphorylation in mice in vivo. Biochem Biophys Res Com- mun, 2014,452 : 8 ~ 13.
  • 7Yi W, Sun Y, Yuan Y, et al. Clq/tumor necrosis factor-re- lated protein-3, a newly identified adipokine, is a novel an- tiapoptotic, proangiogenie, and cardioproteetive molecule in the isehemic mouse heart. Circulation, 2012, 125 : 3159 ~ 3169.
  • 8Byerly MS, Petersen PS, Ramamurthy S, et al. Clq/TNF- related protein 4 (CTRP4) is a unique secreted protein with two tandem Clq domains that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem, 2014, 289:4055 ~4069.
  • 9Sehmid A, Kopp A, Aslanidis C, et al. Regulation and function of Clq/TNF-related protein-5 ( CTRP-5 ) in the context of adipocyte biology. Exp Clin Endoerinol Diabetes, 2013, 121 : 310 ~317.
  • 10Kim MJ, Lee W, Park EJ, et al. ClqTNF-related protein- 6 increases the expression of interleukin-10 in macropha- ges. Mol Cells, 2010, 30 : 59 ~64.

同被引文献166

  • 1涂剑,严鹏科,廖端芳.亲环素A生物学功能的研究进展[J].中国动脉硬化杂志,2005,13(2):236-238. 被引量：6
  • 2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33004
  • 3沈方方,罗娟,金晟娴,曾昭淳.低氧微环境中肿瘤的能量代谢[J].生命的化学,2007,27(1):58-61. 被引量：8
  • 4McAlpine J N, Hanley G E, Woo M M, et al. Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention [ J/OL ]. Am J Obstet Gynecol, 2014, 210 (5) : 471. e1 - e11. doi: 10. 1016/j. ajog. 2014.01. 003.
  • 5Kuchenbaecker K B, Ramus S J, Tyrer J, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer[ J ]. Nat Genet, 2015, 47(2) : 164-171.
  • 6Riester M, Wei W, Waldron L, et al. Risk prediction for late-stage ovarian cancer by meta-analysis of 1525 patient samples[ J]. J Natl Cancer Inst, 2014, 106 (5). pii: dju048, doi: 10. 1093/jnci/ dju048.
  • 7Burger R A, Brady M F, Bookman M A, et al. Risk factors for GI adverse events in a phase Ⅲ randomized trial of bevacizumab in first-line therapy of advanced ovarian cancer: A Gynecologic Oncology Group Study[ J]. J Clin Oncol, 2014, 32(12) : 1210 -1217.
  • 8Devapatla B K, Sharma A, Woo S. Interleukin-8 mediates resistance to anti-VEGF therapy in ovarian cancer [ J]. Cancer Res, 2014, 74( 19 Suppl) : 2999.
  • 9Carbone F, Math F, Montecucco F. The role of adipocytokines in atherogenesis and atheroprogression [ J ]. Curr Drug Targets, 2015, 16(4) : 295 -320.
  • 10Lei H, Wu D, Wang JY, et al. Clq/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/ MRTF-A pathway and inhibiting myofibroblast differentiation[ J/OL]. Basic Res Cardiol, 2015, 110(4) : 35. doi: 10. 1007/s00395 - 015 -0492 -7.

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生理科学进展
2015年 第1期

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