磷酸钙纳米材料的制备、性能及应用

Preparation, properties and applications of calcium phosphate nanostructured materials

磷酸钙作为生物体硬组织中主要的无机成分,具有良好的生物相容性、生物活性及生物可降解性,广泛应用于骨组织与牙齿修复和替换、药物输运和控制释放、基因转染及诊断成像等生物医学领域。人工合成磷酸钙材料的组成、结构、尺寸、形貌和结晶度等特性均与材料的制备方法有关,且材料的这些特性对其应用起到决定性作用。因此,发展不同的方法制备出具有特定组成、结构、尺寸、形貌、结晶度和性能的磷酸钙纳米材料对其应用至关重要。本文综述近年来在磷酸钙纳米材料的制备、表征、性能和应用研究方面所取得的最新进展,讨论室温制备法、溶剂热/水热合成法、微波辅助快速合成法、静电纺丝法及含磷生物分子磷源合成法等制备方法,分析磷酸钙纳米材料的性能及其在药物装载和可控释放、蛋白质吸附及释放、生物成像等领域的应用,展望磷酸钙纳米材料研究领域的发展趋势。

As the important inorganic component of biological hard tissues, calcium phosphate materials have high biocompatibility,bioactivity and biodegradability. Therefore, they are widely investigated and used in various biomedical fields, such as bone and tooth repair and replacement, drug delivery, gene transfection and diagnostic imaging. The chemical composition, structure, crystallite size,morphology, and crystallinity of the synthetic calcium phosphate materials, which are strongly influenced by their preparation methods,play a decisive role in their applications. Therefore, to develop various synthetic methods for the desirable materials is important for their applications. This paper reviews recent research progress of our group in the preparation, characterization, properties and applications of calcium phosphate nanostructured materials, focusing on the preparation methods, including room- temperature synthesis, solvothermal/hydrothermal synthesis, microwave- assisted rapid synthesis, electrospinning, and phosphorus- containing biomolecules based synthesis, and their applications in drug delivery, protein adsorption and release, and bioimaging. The future research trends are also discussed.