血清肿瘤标志物在早期小细胞肺癌辅助诊断中的临床价值

Clinical value of serum tumor markers in diagnosis of early-stage small cell lung cancer

目的探讨3种血清肿瘤标志物在早期小细胞肺癌辅助诊断中的应用价值,并选择最理想的血清肿瘤标志物。方法采用免疫放射分析法对各病理类型早、晚期肺癌及健康人和肺部良性病变者血清中NSE、CYFRA21-1、CEA含量进行测定。结果早期小细胞肺癌患者血清NSE阳性率及浓度水平显著高于肺部良性病变组、健康组及早期肺腺鳞癌,差异均有统计学意义(P<0.01);NSE对早期小细胞肺癌检测的阳性率明显高于CYFRA21-1、CEA,差异均有统计学意义(P<0.01);CYFRA21-1、CEA分别对早期鳞癌、腺癌检测的阳性率明显高于早期小细胞肺癌,差异有统计学意义(P<0.05);早期小细胞肺癌血清NSE阳性率及浓度水平低于晚期小细胞肺癌,差异均有统计学意义(P<0.05)。结论血清NSE是早期小细胞肺癌的敏感指标,有利于早期小细胞肺癌的临床辅助诊断。

Objective To evaluate the regimens of three serum tumor markers in lung cancer diagnosis.Methods The serum levels of the three tumor markers（NSE,CEA,CYFRA21-1）were detected by ELISA in patients with lung cancer,healthy adults and patients with respiratory infection,respectively.Results The sensitivity and levels of the NSE in patients with early-stage small cell lung cancer were remarkably higher than those in healthy adults and patients with respiratory infection（P〈0.01）.The sensitivity of the NSE in diagnosing early-stage small cell lung cancer was remarkably higher than the CEA and CYFRA21-1（P〈0.01）.Both the sensitivity of the CEA and the CYFRA21-1in diagnosing early-stage squamous and lung adenocarcinoma was remarkably higher than that in the early-stage small cell lung cancer（P〈0.05）.The sensitivity and levels of the NSE in patients with early-stage small cell lung cancer were remarkably lower than those in advanced small cell lung cancer（P〈0.05）.Conclusion The NSE is a sensitive index for early-stage small cell lung cancer,clinically assisting in the diagnosis the of early-stage small cell lung cancer.