阿维A联合复方氟米松软膏外用治疗寻常型银屑病的疗效观察

Efficacy and safety of acitretin combined with compound flumetasone ointment for the treatment of psoriasis vulgaris

目的观察阿维A联合复方氟米松软膏外用对治疗寻常型银屑病的临床疗效及安全性。方法选择我科收治的80例寻常型银屑病患者,随机分为治疗组和对照组各40例,治疗组给予口服阿维A胶囊联合外用复方氟米松软膏,对照组仅给予口服阿维A胶囊,疗程均为6周。以银屑病的皮损面积和严重程度(PASI)对两组患者进行疗效评价,同时观察两组患者治疗过程中出现的不良反应。结果治疗第6周时治疗组和对照组的有效率分别为87.5%和67.5%,差异有统计学意义(P<0.05);第6周时治疗组的PASI评分(3.03±1.53)明显低于对照组(5.86±2.36),差异有统计学意义(P<0.05)。个别患者在用药过程中出现的不良反应有血脂轻度升高、口唇干、皮肤干燥,症状均较轻微。结论阿维A联合复方氟米松软膏外用对治疗寻常型银屑病疗效确切,安全性高。

Objective To observe the clinical efficacy and safety of acitretin combined with compound flumetasone ointment for the treatment of psoriasis vulgaris.Methods Eighty psoriasis vulgaris patients admitted to our department were randomly divided into treatment group and control group with 40 cases in each group.The treatment group received oral acitretin capsules combined with compound flumetasone ointment,and the control group only received oral acitretin capsules,a course of six weeks.Two groups of patients were evaluated according to psoriasis area and severity of lesions（PASI）,and adverse reactions were observed.Results The treatment group and the control group showed statistical differences,and the rate was 87.5% and 67.5%,respectively,in the first 6weeks of treatment.At the same time,PASI in the treatment group was lower than that in the control group（3.03±1.53 vs 5.86±2.36）,and the difference was statistical.Adverse reactions observed during treatment in both groups were elevated blood lipids,mild dry lips,dry skin and mild symptoms.Conclusion Acitretin combined with compound flumetasone ointment for the treatment of psoriasis vulgaris is effective and safe.