靶向性抗肺癌新药ZP-1在不同溶液中的稳定性研究

Study on the stability of anti-lung cancer targeting drug ZP-1 in different solution

目的研究靶向性抗肺癌新药ZP-1在不同溶液中的稳定性,为ZP-1的深入研究提供理论依据。方法将ZP-1分别溶解于0.9%(质量浓度,下同)注射用生理盐水、无菌注射用水、5%(质量浓度,下同)葡萄糖注射液中,采用高效液相色谱法检测以上溶液中ZP-1的质量分数变化,以及不同温度下和光照条件下的质量分数变化。结果 ZP-1溶于0.9%注射用生理盐水中,分别于15、25、30℃条件下放置24 h,质量分数分别为99.22%、100.15%、98.96%,稳定性良好;ZP-1在无菌注射用水和5%葡萄糖注射液中稳定性不好,放置24 h相对质量分数分别下降为62.40%、68.61%。结论靶向性抗肺癌新药ZP-1在0.9%注射用生理盐水中具有良好的稳定性。

Objective To determine the stability of ZP-1 in different solution for providing theoretical basis for its intensive research. Methods HPLC was used to determine the content change of ZP-1 in different solvents（ 0.9% sodium chloride injection,sterile water for injection,5% glucose injection）,temperature and illumination. Results ZP-1 was stable for 24 hours in 0.9% sodium chloride injection at 15,25,30 ℃,and the content of ZP-1 was 99.22%,100.15%,98.96%,respectively. ZP-1 was unstable when it was dissolved in the sterile water for injection and the 5% glucose injection,and the content of ZP-1 was 62. 40% and68. 61%,respectively. Conclusion ZP-1 is stable in the 0.9% sodium chloride injection.