摘要
目的:探讨清热化湿方辅治慢性糜烂性胃炎脾胃湿热型患者的临床疗效、安全性、复发率及其对机体炎性因子水平的影响。方法:选取慢性糜烂性胃炎脾胃湿热型126例,随机分为观察组与对照组,每组63例。对照组给予西医常规治疗,观察组在对照组的基础上辅以清热化湿方治疗,两组均治疗4周。评价两组患者治疗前后的炎性因子水平,包括C反应蛋白(CRP)和白细胞介素-6(IL-6)水平,临床疗效以及不良反应,随访6个月观察治疗有效患者的复发情况。结果:治疗前,两组患者的血CRP、IL-6水平比较,差异均无统计学意义(t=0.00-0.97,P〉0.05)。治疗后,两组CRP、IL-6水平均降低(t=3.56-7.31,P〈0.05或P〈0.01);且观察组CRP、IL-6水平均低于对照组水平(t=3.95、4.20,P〈0.05)。观察组与对照组总有效率分别为90.48%、80.95%(χ2=3.67,P〈0.05)。治疗过程中,观察组与对照组各有1例患者略感轻微恶心,未呕吐;观察组另有1例患者轻微皮肤症状。治疗结束6个月后,随访治疗有效患者,观察组及对照组复发率分别为5.56%、20.00%(χ2=6.77,P〈0.01)。结论:清热化湿方辅治慢性糜烂性胃炎脾胃湿热型患者具有较好的临床疗效,短期治疗后患者的炎症状态得以缓解,临床症状迅速消失或缓解,且具有较高的安全性和较低的复发率,优于单纯西医常规方法。
Objective: To explore the clinical effect,safety,recurrence rate and its influence on serum inflammatory factors of treating chronic erosive gastritis patients of damp- heat in spleen and stomach type by Qingre Huashi recipe.Methods: 126 patients with chronic erosive gastritis of damp- heat in spleen and stomach type were selected and divided into observation group and control group,63 cases in each group. Patients in control group were given conventional treatment of western medicine and patients in observation group were treated by Qingre Huashi recipe based on control group and two groups were both treated for 4 weeks. Serum inflammatory factors including C- reaction protein( CRP) and interleukin- 6( IL- 6) of two groups before and after treatment were evaluated and the clinical effect and adverse reaction were also observed and after following up for 6 months,we observed valid patients' recurrence rates. Results: Before treatment,there was no statistical difference on serum CRP and IL- 6 in two groups( t = 0. 00 - 0. 97,P 0. 05). After treatment,two groups' serum CRP and IL- 6 were both decreased( t = 3. 56 - 7. 31,P 0. 05 or P〈 0. 01) and observation groups' level was lower than that of control group( t = 3. 95,4. 20,P 0. 05). Total effective rate in observation group and control group was 90. 48% and 80. 95%( χ2= 3. 67,P 0. 05). During treatment,there was one patient feeling mild nausea,yet without vomiting in two groups and one patient in observation group had minor skin conditions. Following up valid patients for 6 months after treatment,the recurrence rates in observation group and control group were 5. 56% and20% respectively( χ2= 6. 77,P 0. 01). Conclusion: It has good curative effect of treating chronic erosive gastritis patients of damp- heat in spleen and stomach type by Qingre Huashi recipe. The inflammatory state alleviates after short-term treatment and clinical symptoms quickly disappear or relieves. It also has higher safety and lower recurrence rate,soit is better than routine method of western medicine.
出处
《中华中医药学刊》
CAS
北大核心
2015年第3期743-745,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
慢性糜烂性胃炎
炎性因子
脾胃湿热型
清热化湿方
中西医结合
chronic erosive gastritis
inflammatory factors
damp-heat in spleen and stomach type
Qingre Huashi recipe
combination of Chinese traditional and Western medicine