晚期肺鳞癌血清鳞癌相关抗原检测的临床意义

Clinical significance of serum squamous cell carcinoma related antigen detection in advanced lung squamous cell carcinoma

目的探讨晚期肺鳞癌血清鳞癌相关抗原(SCC-Ag)检测的临床价值。方法 80例肺癌患者为研究对象,其中鳞癌50例,腺癌14例,小细胞肺癌(SCLC)11例,大细胞肺癌(LCLC)5例,另选45例良性病变患者,对所有患者进行SCC-Ag检测。结果肺鳞癌阳性率为68.00%,肺腺癌阳性率14.29%,SCLC阳性率18.18%,LCLC阳性率20.00%,对照组2.22%。经手术前后动态观察显示,根治术后SCC-Ag可在3 d内转阴,与其他术式比较差异有统计学意义(P<0.05)。结论 SCC-Ag为肺鳞癌特殊标记物,是对患者手术效果与远期预后进行预测的重要参考指标。

Objective To investigate the clinical value of serum squamous cell carcinoma related antigen（SCC-Ag） detection in advanced lung squamous cell carcinoma. Methods Among the study subjects as 80 lung cancer patients, there were 50 cases with squamous cell carcinoma, 14 cases with adenocarcinoma, 11 cases with small cell lung cancer（SCLC）, and 5 cases with large cell lung cancer（LCLC）. Another 45 patients with benign lesion were selected as well. All the patients received SCC-Ag detection. Results The positive rate of lung squamous cell carcinoma was 68.00%, that of lung adenocarcinoma was 14.29%, that of SCLC was 18.18%, that of LCLC was 20.00%, and that in the control group was 2.22%. The result of dynamic observation before and after surgery showed that SCC-Ag turned to be negative within 3 d after surgery, and it had statistically significant difference with other methods（P〈0.05）. Conclusion SCC-Ag is the specific marker for lung squamous cell carcinoma, and it provides an important reference index for the prediction of surgery effect and long-term prognosis for patients.