基于数据挖掘的国医大师颜正华含白芍处方用药规律研究

Analysis on the medication rules of state medical master Yah Zhenghua from the prescriptions containing Radix Paeoniae Alba based on data mining

目的探讨国医大师颜正华教授处方用药规律。方法收集颜正华教授在北京中医药大学国医堂出诊处方中含有白芍的处方，基于中医传承辅助系统构建数据库，使用软件的统计报表模块、数据分析模块，关联规则apriori算法等数据挖掘方法，分析含白芍处方中单味药物频次、药物组合频次、关联规则与核心药物组合等。结果含白芍处方常用于治疗眩晕、胃痛、反酸等病证，高频次药物包括赤芍、陈皮、丹参、当归、茯苓等，高频次药物组合包括“白芍，赤芍”“丹参，白芍”“白芍，陈皮”等，置信度≥1的关联规则包括“赤芍-白芍”“龙骨-牡蛎”“当归，赤芍-白芍”“赤芍，桑寄生-白芍”等。结论颜正华教授含白芍处方所用药物多具补血活血、安神之功效，用药较为集中，组方法度清晰。

Objective To explore the medication rules of State Medical Master Yah Zhenghua. Methods The prescriptions containing Radix Paeoniae Alba that prescribed by Pro. Yan were collected to build a database based on traditional Chinese Medicine （TCM） inheritance assist system. After analyzed by the statistical reports module and the data analysis module which were from TCM inheritance assist system, and the methods of data-mining that including association rules and apriori algorithm, the frequency of single medicine, the frequency of drug combination, the association rules between drugs and core drug combinations which all were including Radix Paeoniae Alba can be get from the database. Results The prescriptions including Radix Paeoniae Alba were commonly used to treat megrim, stomach-ache, acid regurgitation and other syndromes. The highest frequency used drugs were Radix PaeoniaeRubra, PeriearpiumCitriReticulatae, Radix SalviaeMiltiorrhizae, Radix AngelicaeSinensis, Poria, and so on. The most frequency drug combinations were ＂RadxPaeoniae Alba, Radix PaeoniaeRubra＂, ＂Radix SalviaeMiltiorrhizae, Radix Paeoniae Alba＂, and ＂Radix Paeoniae Alba, PericaxpiumCitriReticulatae＂. The drug association rules that the confidence was more than once were ＂Radix PaeoniaeRubra Radix Paeoniae Alba＂, ＂OsDraconis Concha Ostreae＂, ＂Radix AngelicaeS - Radix Paeoniae Alba＂, and ＂Radix PaeoniaeRubra, HerbaTaxilli - Radix Paeoniae Alba＂, and so on. Conclusions The drugs in the prescriptions containing Radix Paeoniae Alba that built by Pro. Yan mostly had the effects of enriching the blood and invigorating the circulation of blood, relieve uneasiness of mind and body tranquilization, which reflected the clearly thought when constructing prescriptions.