基于聚类分析的中医脂肪肝辨证分型与客观化指标的关系探讨

Study on the relationship between TCM differentiation types of fatty liver and its objective indexes

目的探讨脂肪肝的聚类分析分型与临床客观化指标的关系。方法采用横断面研究方法，利用脂肪肝中医四诊表现临床观察表采集患者资料，采用聚类分析对患者进行分型，研究各种分型客观化指标的差别。结果聚类分型各客观化指标比较发现，脾虚湿盛组脂肪肝严重度较心肝阴虚组大（χ^2=8．218，P=0．041）；脾胃气虚组有抽烟史者较少（χ^2=8．416，P=0．038）。脾虚湿盛组天冬氨酸转氨酶、总蛋白、碱性磷酸酶、腰臀比较高，血清白蛋白较低。结论脂肪肝各分型客观化指标的差异，可充实辨证论治的内容，为脂肪肝的微观辨证提供依据。

Objective To investigate the relationship between syndrome differentiation types and the objective indexes of fatty liver. Methods A cross-sectional study was adopted. Clinical observation table of fatty liver for TCM diagnostic performance was used to collect the data of patients and cluster analysis was adopted for syndrome differentiation. The difference of the objective indexes among different syndromes was studied. Results Fatty liver showed more severity in spleen Qi deficiency and dampness group compared with heart and liver yin deficiency group （χ^2=8.218, P=0.041 ） . Patients in the spleen and stomach Qi deficiency group had less smoking history （χ^2=8.416, P=-0.038） . Patients in the spleen Qi deficiency and dampness group had higher AST, TP, ALP and WHR indexes and lower Alb. Conclusions Differences of objective indexes in different fatty liver syndromes can be used for enriching syndrome differentiation contents, and provide the basis for microcosmic syndrome differentiation of fatty liver.