临床药师对临床不合理用药的药学干预分析

Analysis of Clinical Pharmacists in Clinical Pharmacy Intervention of Irrational Drug Use

目的探讨临床药师对临床不合理用药的药学干预前后两年的用药改善情况。方法选取1 000份医嘱,比较医嘱中不合理用药、重复给药、无适应证给药、抗菌药物使用情况,追踪对应患者的药物费用、抗菌药费用、住院时间、服药依从性和不良反应发生率,并进一步探讨最优干预办法,并选取干预后的1 000份医嘱对以上情况进行观察。结果实施药学干预后,不合理医嘱、重复给药、无适应证给药等情况明显减少;抗菌药使用量大大减少;患者医疗费用减少,病程缩短;患者服药依从性和不良反应发生率,与干预前比较,差异有统计学意义(P<0.05)。结论临床药师干预临床用药,可明显降低用药不合理现象的发生,有效改善了患者的用药情况,降低药物不良反应的发生率及患者的病死率,同时提高治疗效果。

Objective To investigate the clinical pharmacist interventions on clinical pharmacy irrational drug use before and after two years of treatment to improve the situation.Methods Select 1 000 copies of orders,orders incomparison of irrational use of drugs, repeated administration,no indications to medicine,the use of antibacterial drugs, drug costs,patient tracking corresponding antibacterial drug cos,time,medication compliance and the incidence of adverse reactions among inpatients,and to further explore the optimal intervention measures.Then choose 1 000 copies of orders to observation the drug costs,antibacterial drug cost,hospitalization time,medication compliance and adverse reaction rate after intervention.Results After the implementation of pharmaceutical intervention,irrational prescriptions,repeated doses,significantly reducing administration and so no indications;antibiotic use is greatly reduced;reduce patient medical costs,shorten the course;patient medication compliance and adverse reaction rates changed significantly,compared with pre-intervention,and the difference was statistically significant（P〈0.05）. Conclusion Clinical pharmacists in clinical medication,can significantly reduce the medication unreasonable phenomenon,effectively improve the medication of patients,reduce the incidence of adverse drug reactions rate and mortality,and improve treatment efficacy.