白色念珠菌与口腔扁平苔藓的相关性研究

Study on the correlation between Candida albicans and oral lichen planus

目的探讨白色念珠菌与口腔扁平苔藓的相关性。方法选取本院非糜烂型口腔扁平苔藓患者40例及糜烂型口腔扁平苔藓患者36例分别作为观察1组和观察2组,选取40例无口腔疾患的健康者作为对照组。应用棉拭子法采样,于沙氏琼脂培养基中37℃培养24~48小时后观察菌落形态,鉴定不同菌种,比较合并白色念珠菌感染率。测量通过真菌检测后的76例口腔扁平苔藓患者口腔皮损面积,比较不同口腔皮损面积患者白色念珠菌的感染率。结果观察1组、观察2组及对照组白色念珠菌检出率分别为32.5%、69.4%和7.5%,组间比较差异显著（P〈0.05）。口腔皮损面积型〉2 cm^2和〈2 cm^2患者的白色念珠菌检出率分别为47.6.%和23.5%,差异具有显著性（P〈0.05）。结论糜烂型及非糜烂型口腔扁平苔藓与合并白色念珠菌感染明确相关,口腔皮损面积与感染率明显相关,白色念珠菌感染可诱发及加重口腔扁平苔藓。

Objective To investigate the correlation between Candida albicans and oral lichen planus. Method Selected non-erosive type oral lichen planus patients as observation group 1（n = 40） and erosive type oral lichen planus patients as observation group 2（n = 36）. Who had no oral diseases were selected as control group（n = 40）. Adopted a cotton swab sampling on sabouraud agar, after 24 ~ 48 hours, observed colony morphology of 37 ℃culture medium, identificated different strains, compared candida infection rate. Through the detection of fungi, 76 patients with oral lichen planus measuring oral lesion area were divided into 〉2 cm^2 and〈 2 cm^2, compared infection rate of the two groups. Result Candida albicans detection rate of observation group 1, observation group 2 and control group was 32.5%, 69.4% and 7.5% respectively, the difference between the three groups was significant（P〈0.05）. Candida albicans detection rate in lesion area of observation group was 47.6.% and 23.5%, the difference between the two groups was significant（P〈0.05）. Conclusion Erosive and non-erosive type oral lichen planus is concerned with Candida albicans infection, psoriasis area is concerned with, infection rate, Candida albicans can induce and aggravate oral lichen planus.