血清胱抑素-C与慢性阻塞性肺疾病继发肺动脉高压的相关性

Relationship between serum cystatin C and pulmonary hypertension secondary to COPD

目的探讨血清胱抑素(Cys-C)与慢性阻塞性肺疾病继发肺动脉高压相关性。方法回顾性分析2012年9月至2014年1月皖南医学院第一附属医院呼吸科慢性阻塞性肺疾病144例住院患者的临床资料。将144例入选病例分为肺动脉压正常组和增高组,比较两组一般情况、基础疾病情况、Cys-C和住院时间。结果肺动脉压增高组Cys-C明显高于肺动脉压正常组Cys-C(0.97±0.43 vs 1.22±0.36),差异有统计学意义(P<0.001)。而年龄、性别、高血压、糖尿病、冠心病、Pa O2、Pa CO2及住院时间两组差异均无统计学意义(P>0.05)。Pearson相关性分析结果示Cys-C与肺动脉高压呈正相关性(r=0.614,P<0.01)。结论慢阻肺继发肺动脉高压患者体内Cys-C明显增高,并与肺动脉高压严重程度呈正相关。Cys-C可作为反应慢性阻塞性肺疾病继发肺动脉高压严重程度的指标。

Objective To explore the relationship between serum cystatin C( Cys-C) and pulmonary hypertension secondary to chronic obstructive pulmonary disease( COPD). Methods The clinical data of 144 inpatients with COPD in our hospital from Sep 2012 to Jan2014 was retrospective analyzed. All cases were divided into hypertension group and normal group according to the pulmonary artery pressure.General conditions,underlying diseases,serum Cys-C and hospital stays of patients in the two groups were compared separately. Results Serum Cys-C concentration in the hypertension group was much higher than that of the normal group( 0. 97 ± 0. 43 vs 1. 22 ± 0. 36),and the difference between the two groups was statistically significant( P < 0. 001). However,there was no significant difference in the age,sex,hypertension,diabetes,coronary heart disease,Pa O2,Pa CO2 and hospital stays of both groups. Pearson correlation analysis showed that serum Cys-C was positively related to pulmonary hypertension( r = 0. 614,P < 0. 01). Conclusion The serum Cys-C concentration increases significantly in patients with pulmonary hypertension secondary to COPD,and shared positive correlation with the severity of pulmonary hypertension. It is reasonable to use Cys-C as a index to evaluate the severity of pulmonary hypertension secondary to COPD.