临产高危妊娠患者凝血四项和D-D水平变化研究

Analysis of coagulation routine test and D-dimer in high-risk pregnancy patients

目的探讨临产高危妊娠患者凝血四项和D-二聚体(D-D)水平变化。方法选取2013年7月-2014年2月本院收治的临产孕妇240例,参照上海市高危妊娠评分标准,分为A级组57例,B级组70例,C级组69例,正常妊娠组44例。检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-D,与未孕健康育龄期女性24例正常对照比较分析。结果各妊娠组PT、APTT值与未孕组差异无统计学意义(P>0.05)。TT值仅A级组显著低于未孕组(P<0.05)。各妊娠组FIB和D-D水平均显著高于未孕组(P<0.01),但C级组FIB水平显著低于正常妊娠组(P<0.05),D-D水平随高危妊娠程度加重显著升高(P<0.01)。结论凝血常规并不能及时敏感地提示机体的高凝状态,FIB和D-D检测在高危妊娠患者中更应重视。

Objective To explore the level changes of coagulation routine test and D- dimer in high- risk pregnancy patients.Methods According to Shanghai high risk pregnancy score standard,240 high- risk pregnancy patients in our hospital collected from Jun. 2013 to Feb. 2014 were divided into Group A（57）,Group B（70）,Group C（69）,and Normal Group（44）. PT,APTT,TT,FIB and D- D of them were detected and compared with 24 cases non- pregnant women. Resu Its There＇s no significant difference in PT,APTT between pregnant and non- pregnant women（ P 0. 05）. Compared with non- pregnant women,TT showed a remarkable decline only in group A（ P 0. 05）. FIB and D- D showed significant increase over non-pregnant women（ P 0. 01）,but the FIB level in group C was significantly lower than that of nomal group（ P 0. 05）. D- D significant increased over the high- risk pregnancy degrees（ P 0. 01）. Conclusion Coagulation routine test can not timely and sensitively reflect hypercoagulable state of high- risk pregnancy patients. FIB and D- D detection should be enhanced significantly in high- risk pregnancy patients.