伏立康唑治疗血液病合并侵袭性真菌病61例临床观察

Clinical observation on voriconazole in treatment of 61 cases of hematologic disease complicated with invasive fungal disease

目的:观察伏立康唑治疗血液病合并侵袭性真菌感染(IFD)患者的疗效。方法:回顾性分析61例伏立康唑治疗血液病合并IFD患者的临床资料。结果:足量足疗程的伏立康唑治疗血液病合并IFD的总有效率为67.2%,其中预防治疗31例中24例(77.4%)有效,经验治疗24例中13例(54.2%)有效,两者的差异无统计学意义(P>0.05)。9例患者用药后出现肝功能轻度异常,2例出现皮疹,1例出现恶心呕吐,均不影响治疗。结论:足量足疗程的伏立康唑治疗血液病合并IFD患者有一定疗效,不良反应较少。

Objective： To observe the therapeutic effect of voriconazole for patients with hematologic diseases complicated with invasive fungal infection（ IFD）. Methods： Clinical data of 61 cases with hematologic diseases complicated with IFD treated by voriconazole were analyzed retrospectively. Results： With sufficient dosage and full course of treatment of voriconazole in 61 cases of hematologic diseases complicated with IFD,the total effective rate was 67. 2%,of which preventive treatment（ 31 cases）,24 cases（ 77. 4%） was effective,and empiric therapy（ 24 cases）,13 cases（ 54. 2%） was effective. There was no statistically significance between the two kinds of treatment（ P 〉0. 05）. Of 61 patients,9 patients presented moderate liver function damage,2 cases with skin rash,one case with nausea and vomiting,but all did not affect the treatment. Conclusion： Sufficient dosage and course of voriconazole treatment in treatment of patients with hematologic disease complicated with IFD showed a high efficacy and less side effects.