摘要
目的：探讨＞70岁老年患者慢性胃炎中胃蛋白酶原（PG）Ⅰ、Ⅱ变化及临床意义。方法选择经胃镜和病理诊断的慢性胃炎240例，分为＞70岁老年研究组（慢性非萎缩性胃炎60例＋慢性萎缩性胃炎60例）和20-60岁的中青年对照组（慢性非萎缩性胃炎60例＋慢性萎缩性胃炎60例）。分别测定患者血清中的PGⅠ、PGⅡ，计算PGⅠ/PGⅡ（PGR）。结果对照组中慢性非萎缩性胃炎和慢性萎缩性胃炎患者PGⅠ、PGR有统计学差异（P＞0.05）；研究组中慢性萎缩性胃炎较慢性非萎缩性胃炎患者PGⅠ、PGR明显下降（P＜0.05）；研究组较对照组PGⅠ、PGR降低（P＜0.05）。根据ROC曲线＞70岁老年慢性萎缩性胃炎患者PGⅠ和PGR的界值分别为97.25μg/L、6.75。结论血清PG检测对老年患者慢性萎缩性胃炎的筛查有意义，针对老年患者需进一步研究确定其参考范围。
Objective To investigate the serum levels of pepsinogen （PG）ⅠandⅡ in elderly patients with chronic gas-tritis and its clinical significance. Methods One hundred and twenty patients with chronic gastritis aged over 70y, including 60 cases of atrophic gastritis and 60 of non- atrophic gastritis were enrol ed in the study as elderly group, 120 patients aged 20-60y, including 60 cases of atrophic gastritis and 60 of non- atrophic gastritis served as control group. Serum PGⅠand PGⅡ levels were measured and the ratio of PGⅠ/PGⅡ （PGR） was calculated. Results There were different significance of PGⅠand PGR between non- atrophic chronic gastritis patients and atrophic chronic gastritis patients in control group. While in case group, the PGⅠand PGR levels in non- atrophic chronic gastritis patients were lower than that of atrophic chronic gastritis patients（P〈0.05）. The PGⅠand PGR levels in case group were lower than that of control group （P〈0.05）. According to ROC cure, the cut- off of PGⅠand PGR was 97.25μg/L and 6.75 respectively in chronic gastritis patients over 70 years old. Conclusion Serum PG mea-surement could be used to screen elder chronic atrophic gastritis patients. And its medical reference change should be further explored.
出处
《浙江医学》
CAS
2015年第1期42-43,77,共3页
Zhejiang Medical Journal
