高龄老年男性腰椎骨密度独立相关因素的研究

Factors associated with lumbar bone mineral density in old-aged men

目的通过分析高龄老年(≥80岁)男性腰椎骨密度(LBMD)的独立相关因素,寻找提高高龄老年男性LBMD的方法。方法对1066例高龄老年男性进行LBMD测定、血液生化、骨代谢和生殖激素等指标的检测,运用多元回归分析筛选高龄老年男性LBMD的独立相关因素。结果高龄老年男性LBMD的独立相关因素有体重指数(β=0.018,P<0.01)、Ⅰ型胶原羧基端肽β特殊序列(β=-0.226,P<0.01)、慢性阻塞性肺疾病(β=-0.047,P<0.01)、雌二醇(β=0.002,P<0.01)。结论维持合理的体重指数和雌二醇水平,降低血清Ⅰ型胶原羧基端肽β特殊序列水平,积极防治慢性阻塞性肺疾病,可能是提高高龄老年男性LBMD的重要方法。

Objective To investigate the factors associated with lumbar bone mineral density （LBMD） in old- aged men. Methods A cross- sectional survey was conducted in 1066 men aged 80 and over. LBMD measurement and laboratory tests were performed in all subjects. Univariate analysis and multivariate regression analyses were applied to reveal independent associated factors of LBMD. Results Body mass index （β=0.018, P〈0.01）, serum C- telopeptide of type 1 col agen （CTX,β=- 0.226, P〈0.01）, chronic obstructive pulmonary disease（COPD,β=- 0.047, P〈0.01）, serum estradiol （β=0.002, P〈0.01） were independent associated factors of LBMD. Conclusion Study shows that body mass index, serum estradiol and CTX levels, and COPD are factors associated with LBMD in men aged 80 and over.