解脲脲原体感染与精子形态学相关性研究

Relationship between sperm morphology and Ureplasma urealyticum infection

目的:观察男性生殖道解脲脲原体(Ureaplasma urealyticum,Uu)感染患者的精子形态学分析结果 ,探讨Uu感染对精子形态可能存在的影响。方法:2012年在上海市第一妇婴保健院生殖中心就诊的生育前检查者共258例,经排除影响因素后入组Uu感染的男性患者96例。统一治疗后,按Uu治疗结果分为Uu转阴组和未转阴组2组,比较2组间精子形态学分析结果。结果:Uu转阴组患者治疗前、后的精子正常形态率和精子头部畸形率差异均无统计学意义(P=0.09和P=0.08),但Uu治愈后较治疗前患者的精子尾部畸形率显著降低(P=0.02);而未转阴组治疗前、后的精子正常形态率、头部畸形率及尾部畸形率差异均无统计学意义(P=0.92,P=0.14,P=1.00)。Uu转阴组与未转阴组比较,患者治疗前或后的精子正常形态变化无统计学差异(P=0.83)。结论:总体上看,治疗Uu对精子形态学分析结果无明确意义,但Uu感染者治愈后的精子尾部畸形率显著降低,提示Uu可能会引起精子尾部畸形。

Objective： To compare the difference in sperm morphology before and after antimicrobial treatment in Ureplasma urealyticum（Uu） infected patients, and analyze the possible effect of Uu infection on sperm morphology.Methods： Two hundred and fifty-eight subjects undergone pre-pregnancy examination at Reproductive Medicine Center of Shanghai First Maternity and Infant Hospital in 2012 were collected. After eliminating cases with influencing factors, 96 eligible cases with Uu infection were enrolled and treated with the same therapeutic regimen. The 96 cases were divided into two groups according to the treatment outcome, Uu turning negative group and Uu remaining positive group. Sperm morphology was analyzed before and after treatment in both these 2 groups. Results： In Un turning negative group, percentage of morphology normal sperm and percentage of sperm with abnormal head were similar before and after treatment（P=0.90, P=0.08）, while percentage of sperm with abnormal tail decreased significantly after treatment（P=0.02）. Percentages of morphology normal sperm, sperm with abnormal head and sperm with abnormal tail were similar before and after treatment in Uu remaining positive group（P=0.92, P=0.14, P=1.00）. The morphology changes before and after treatment were not significantly different between Uu turning negative group and Uu remaining positive group（P=0.83）. Conclusions： Uu infection has no evident impact on sperm morphology. However, the percentage of sperm with abnormal tail decreases significantly after treatment in Uu turning negative patients, which denotes that Uu infection may cause abnormality of sperm tail.