高压氧综合治疗急性面神经炎58例疗效分析

Clinical analysis of the effects of hyperbaric oxygen on the treatment of 58 cases of acute face neuritis

目的 观察高压氧（hyperbaric oxygen,HBO）联合药物综合治疗急性面神经炎的疗效.方法 按照病例纳入标准,选择临床急性面神经炎患者116例.经患者知情同意,签署知情同意书,并经医院伦理委员会同意后,将116例患者分为对照组和HBO组,每组58例.（1）对照组：甲钴胺注射液500 μg肌肉注射,1次/d,连用3周.维生素B1注射液1 mg肌肉注射,1次/d连用3周.阿昔洛韦片400 mg口服,3次/d,加用3周.激素冲击治疗：地塞米松10 mg＋ 5％葡萄糖注射液250 ml静滴,1次/d,10 d后逐步减量;全身支持治疗：低分子右旋糖酐500 ml＋注射用辅酶A 50 U静滴,1次/d,连用3周.（2） HBO组：在对照组药物治疗基础上,加用HBO治疗.HBO治疗：采用0.25 MPa （2.5 ATA）,升压20 min,稳压吸氧60 min（带面罩间歇吸氧）,氧浓度为99.5％,减压30 min.1次/d,10d为1个疗程.以上方法均治疗3周后进行疗效评价.结果 2组急性面神经炎患者经过3周治疗后,面神经功能评分较治疗前均增加[对照组：治疗前（8.8±4.4）分、治疗后（21.3±5.5）分;HBO组：治疗前（8.7±4.5）分、治疗后（26.4±3.4）分],差异均有统计学意义（P＜0.01）;HBO组在3周治疗后的评分明显高于对照组（P＜0.05）.结论 HBO综合治疗急性面神经炎疗效明显.

Objective To observe the effects of HBO combined with comprehensive drug treatment on 58 cases of acute face neuritis.Methods In accordance with the case selection criteria,116 case of acute face neuritis were chosen for the study.With the knowledge and consent of the patients and following the signing of the letter of agreement and with the agreement of the Hospital Ethic Committee,1 16 patients were divided into 2 groups：the experimental group and the control group,each consisting of 58 patients.The patients in the control group were only treated with regular drug treatment,while the patients in the experimental group were offered HBO treatment and regular drug treatment as well.They were all treated for a succession of 3 weeks and observation was made on the therapeutic results of both groups.Results After 3 weeks of treatment,facial nerve function scores for the patients of both groups all increased when compared with those before treatment,with statistical significance （P 〈 0.01）.Scores for the patients in the experimental group were significantly higher than those for the patients of the control group （P 〈 0.05）.Conclusions Comprehensive HBO treatment seemed to produce significant effects in the treatment of acute face neuritis.