酒精性肝硬化与Hp感染相关性的Meta分析

Alcoholic cirrhosis and Hp infection in Meta-analysis

目的：探讨酒精性肝硬化与幽门螺旋杆菌（Helicobacter pylori ，Hp ）感染的相关性。方法收集已发表的酒精性肝硬化患者感染 Hp 发病率的文献，记录发表年份、地区、第一作者、研究人群及检测方法等，建立 Meta 回归模型并同时进行亚组分析及异质性检测。结果共搜索318篇文献，8篇符合入选标准。入选文献共纳入人数14226名，总的 Hp 感染率为70．67％。Meta 分析结果揭示酒精性肝硬化患者及对照组之间 Hp 感染率无明显差异（OR ＝0．82，95％CI ：0．35～1．91，P ＜0．01）。亚组分析提示欧洲人群中酒精性肝硬化患者的 Hp 感染率明显高于对照组，而亚洲人群则无明显差异。结论欧洲人群中酒精性肝硬化患者的 Hp 感染率明显高于对照组。

Objective To quantify the association between alcoholic cirrhosis and H .Pylori infection.Methods Published information on H .Pylori prevalence in patients with alcoholic cirrhosis was collected to assess the potential associations between H .Pylori infection and alcoholic cirrhosis risk.Eligible studies were included for analysis.Data on the publication year,detection methods and study populations were summarized.Meta-regression models and subgroup analyses were established to screen the factors resulting heterogeneity.Results Among the 318 articles retrieved,8 met the inclusion criteria.These studies involved 14226 cases,with a total H .Pylori infection rate of 70.67%.This meta-analysis showed no significantly difference in H .Pylori infection rate between the patients with alcoholic cirrhosis and the controls （OR）=0.82,95% CI ：0.35~1 .91 ,P 〈0.0001）.Subgroup analysis revealed that unlike Asian,European subjects demonstrated a significantly higher prevalence of the H .Pylori infection in the patients with alcoholic cirrhosis. Conclusion The pooled data suggest that alcoholic cirrhosis is significantly associated with higher H .Pylori infection rate in Europe.Large-scale and multicenter studies are needed for further investigation on the relation between alcoholic cirrhosis and H.Pylori infection.