摘要
白细胞介素-1β（IL-1β）涉及多种炎性疾病和自身免疫性疾病.然而,IL-1β在各种疾病导致疼痛的作用机理了解甚少,这意味着从治疗学角度来讲靶向拮抗IL-1β治疗疼痛面临诸多挑战.本篇综述旨在介绍IL-1β在炎性疼痛和神经性疼痛的直接及间接机理,并讨论靶向拮抗IL-1β治疗疼痛的方法及最新研究进展.
Interleukin-1β（IL-1β） has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may be a challenge for approaching the target from a therapeutic stand point. The aim of this brief review is to summarize the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss the research progress of approaches to target block IL-1β production or IL-lβ-re- ceptor.
出处
《实用疼痛学杂志》
2014年第6期462-466,共5页
Pain Clinic Journal
