维吾尔族儿童口腔白色念珠菌的检测及与龋病的关系初探

Oral candida albicans distribution in Uyghur children and its relationship with early childhood caries

目的：研究乌鲁木齐市维吾尔族不同龋敏感性儿童及不同性别儿童牙菌斑和唾液中白色念珠菌检出差异性,并探讨其与龋病的相关性。方法：选择新疆乌鲁木齐市维吾尔族3-5岁儿童104名,通过唾液法与菌斑法采集样本,用科玛嘉念珠菌显色培养基进行口腔白色念珠菌分离培养,生化及PCR分子生物学鉴定。结果：51例高龋组中菌斑法、唾液法得到的白色念珠菌的检出率分别为47.1%和27.5%（P〈0.05）,53例无龋组中分别为3.8%和1.9%（P〉0.05）,高龋组白色念珠菌的检出率高于无龋组（P=0.000）;维吾尔族男、女口腔白色念珠菌的检出无统计学意义（P〉0.05）。结论：口腔白色念珠菌可能是维吾尔族幼儿龋病的危险因素且与性别无关。

AIM： To investigate the oral candida albicans distribution in Uyghur children in Urumqi and to investigate its relationship with early childhood caries（ ECC）. METHODS： Saliva and dental plaque were collected from 104 Uyghur children aged 3- to- 5 year old Uyghur children. The samples were cultured on CHRO Magar candida medium and candida albicans was identified by biochemical identification and PCR methods. RESULTS： In high caries group（ n = 51） the detection rate of candida albicans from plaque and saliva was 47. 1% and 27. 5% respectively（ P〈0. 05）. In non- caries group（ n = 53） 3. 8% and 1. 9% respectively（ P〉0. 05）. Candida albicans detection rate between the 2 groups,P = 0. 000. CONCLUSION： Candida albicans may be one of the important cariogenic microorganisms of ECC in Uyghur children.