肝硬化Child-Pugh评分与血清CA125、CA199水平的关系

Relationship between liver cirrhosis Child-Pugh score and serum CA125,CA199 levels

目的探讨肝硬化患者血清CA125、CA199水平及其与肝功能分级的关系。方法随机抽取新乡市传染病医院2013年1月-2013年6月收治的肝硬化确诊患者52例,检测血清CA125、CA199水平。分析CA125、CA199水平与肝功能分级(Child-Pugh积分法)的关系。结果血清CA125、CA199水平随着肝功能损害程度的加重呈进行性升高,B级较A级、C级较B级均显著升高,差异有统计学意义(P<0.05);伴有腹水患者血清CA125水平明显升高,与无腹水患者相比,差异有统计学意义(P<0.05)。结论血清CA125、CA199可以作为反映肝硬化患者肝功能损害程度的指标之一,对衡量肝硬化患者的预后、预测腹水发生有一定的参考价值。

Objective To investigate the relationship between serum CA125,CA199 levels in patients with liver cirrhosis and liver function classification. Methods Fifty-two patients with liver cirrhosis were selected in the Infectious Disease Hospital of Xinxiang City from Jan. 2013 to Jun. 2013. Relationship between CA125 and CA199 levels and liver function grade（ Child-Pugh method） were analyzed. Results The serum CA125,CA199 levels with worsening liver function damage were progressively increased（ P 〈0. 05）; ascites in patients with serum CA125 levels were significantly increased,compared with patients without ascites had statistical significant（ P 〈0. 05）. Conclusion Serum CA125,CA199 can be used as one of the reflection of the extent of impairment in patients with liver cirrhosis ascites index,and have the certain reference value in predicting the prognosis of patients with liver cirrhosis.