血清低密度脂蛋白胆固醇水平与脑出血的相关性初探

Correlation of Serum Low Density Lipoprotein Cholesterol Level with Intracerebral Hemorrhage

目的探讨血清低密度脂蛋白胆固醇水平与脑出血的相关性.方法采用病例对照研究,收集脑出血患者142例,选取同期在同一医院进行健康体检的中老年人201例为对照组.所有入组脑出血患者接受2次CT扫描.第1次扫描在发病6h内完成,第2次扫描在发病24h内完成.将脑出血组分为血肿扩大组及血肿无扩大组.将脑出血组与对照组2组间的血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白(VLDL)、载脂蛋白A-I(Apo A-I)、载脂蛋白B(Apo B)进行两样本均数比较的t检验,将血肿扩大组与血肿无扩大组2组间的TG、TC、HDL-C、LDL-C、VLDL、Apo A-I、Apo B进行两样本均数比较的t检验.结果脑出血组LDL-C低于对照组,且差异有统计学意义(P<0.05).脑出血血肿扩大组LDL-C低于脑出血血肿无扩大组,差异有统计学意义(P<0.05).结论 LDL-C水平降低与脑出血发生及血肿扩大具有相关性.

Objective To investigate the correlation of serum low density lipoprotein cholesterol level with intracerebral hemorrhage. Methods A case-control study was applied.142 patients with intracerebral hemorrhage were assigned as study group, and 201 healthy subjects as control group. The 142 patients underwent initial computed tomography（CT） within 6 hours and repeated CT within 24 hours of onset. Patients in the study group with intracerebral hemorrhage were divided into the hematoma expansion group and non-hematoma expansion group.The two sample t test was used to compare the serum levels of triglyceride（TG）, total cholesterol（TC）,highdensity lipoprotein cholesterol（HDL-C）, low-density lipoprotein cholesterol（LDL-C）, very low density lipoprotein（VLDL）, apolipoprotein AI（Apo A-I） and apolipoprotein B（Apo B） between intracerebral hemorrhage group and control group. The blood lipid levels were compared between intracerebral hemorrhage hematoma expansion group and non-hematoma expansion group. Results The serum level of low density lipoprotein cholesterol was lower in study group than that of control group（P〈0.05）. The serum level of low density lipoprotein cholesterol was lower in hematoma expansion group than that of non-hematoma expansion group（P 〈0.05）.Conclusion Low density lipoprotein cholesterol level decrease is correlated with the occurrence of intracerebral hemorrhage and hematoma expansion.