亚低温治疗重型颅脑损伤的临床研究

Clinical study of mild hypothermia treatment of severe brain injury

目的 :探讨亚低温对重型颅脑损伤的临床治疗效果。方法 :亚低温治疗组 2 4例 ,均于伤后 2 4h内进行亚低温治疗 ,设定治疗温度为肛温 32～ 35℃。于降温前及亚低温治疗过程中监测体温 (T)、心率 (HR)、血压 (BP)、呼吸 (R)。对照组 2 7例 ,均于出院后评定预后。结果 :亚低温治疗组病人伤后早期较高的心率 (HR)降至正常范围 ;与对照组相比 ,亚低温治疗组未发生严重并发症 ,死亡率下降 ,预后得到显著改善。结论 :亚低温治疗重型颅脑损伤是一种有效的方法 ,无严重并发症 ,可降低死亡率 ,提高生存质量。

Objective:To evaluate the effectiveness of mild hypothermia on patients with severe brain injury.Methods:Retrospective analysis was conducted for 24 patients with severe brain injury(Glasgow Coma Scale Score≤8).All of them received mild hypothermia treatment(the rectal temperature maintained at 32 35℃)for an average period of 4.7 days within 24 hours after brain injury.Before and during cooling,the vital signs were also measured.Another 27 patients served as control.GOS(Glasgow Outcome Scale)was used for the assessment of prognosis in these two groups.Results:During mild hypothermia,the heart rate(HT)decreased.No complications were found in the mild hypothermia group.Mean GOS of the patients at discharge(1 3months atfer injury)was improved and the mortality was lower in mild hypothermia group than that of the control group.Conclusion:In the patients with severe brain injury,mild hypothermia is a effective therapy,which can reduce the mortality and is associated with no complications.