小鼠局灶性脑中风模型研究进展

Research progress of mouse models of focal cerebral stroke

中风是包括大脑缺血性中风,大脑出血性中风(ICH)和蛛网膜下腔出血性中风(SAH)在内的一类神经系统性疾病,其发病率和死亡率居高不下。制作方法简单,可重复性好的动物模型是研究中风损伤发病机制和治疗方法不可或缺的载体,损伤位置、体积、神经功能缺损和脑血流量变化,都可以用来评估模型对于各种治疗方法的潜力。本文将对小鼠的缺血性中风、出血性中风模型的制作方法和经验进行总结同时介绍几种小鼠中风模型的评价方法。

Stroke is a class of neurological disorders including cerebral ischemic stroke,cerebral hemorrhagic stroke（ ICH） and subarachnoid hemorrhagic stroke（ SAH）,which has a high incidence of morbidity and mortality. Simple and reproducible animal model is indispensable for the study of pathogenesis and treatment after stroke insult. Location and size of injury,neurological deficits and cerebral blood flow changes can be used to assess the availability of the model for various treatment methods. Construction methods,designing experience as well as the methods of model assessment were summarized in this article.