氧化应激与肾脏细胞凋亡

Oxidative stress and renal cell apoptosis

氧化应激产生的活性氧(ROS)与细胞凋亡存在密切的关系。ROS可通过激活线粒体、Bcl-2家族、NF-κB及MAPKS家族、Caspase家族等途径引起细胞凋亡,细胞凋亡在肾脏疾病的发病过程中起着重要作用。本文就氧化应激在肾脏疾病发生发展中的作用及其诱导细胞凋亡的机制进行了综述。

Reactive oxygen species（ ROS） resulting from oxidative stress have a close relationship with cell apoptosis. ROS induces cell apoptosis through activating different signaling pathways including mitochondria,Bcl-2,NF-κB,MAPKSand Caspases and so on. Cell apoptosis plays a significant role in the course of kidney diseases. In this paper,the function of oxidative stress in the development and progression of kidney diseases and apoptosis mechanism induced by oxidative stress are reviewed.