VEGF、EGFR的表达与非小细胞肺癌生物学行为的相关性

The correlation between expressions of VEGF and EGFR and biological behavior in non-small cell lung cancer( NSCLC)

目的:检测血管内皮生长因子(vascular endothelial factor,VEGF)和表皮生长因子(epidermal growth factor receptor,EGFR)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达,研究两者与NSCLC生物学行为之间的关系及两者之间的彼此关系。方法:采用免疫组化链霉菌抗生物素蛋白-过氧化物酶连结(streptavidin-perosidase,SP)法检测VEGF、EGFR在112例NSCLC中的表达情况。结果:112例NSCLC中,VEGF、EGFR的阳性表达率分别为56.3%、69.6%。VEGF在NSCLC中的阳性表达与吸烟、分化程度、肿块大小、淋巴结转移及临床分期相关(P<0.05),而与性别、年龄、病变部位、组织学类型无关(P>0.05)。EGFR的阳性表达与年龄、组织学类型、分化程度、肿块大小、淋巴结转移及临床分期相关(P<0.05),而与性别、吸烟、病变部位无关(P>0.05)。VEGF、EGFR在NSCLC中的阳性表达呈正相关关系。结论:VEGF、EGFR在NSCLC的发生、发展过程中起重要作用,可以作为初步判断NSCLC预后的独立指标。

Objective：To explore the correlation of expressions of VEGF and EGFR and their associations with the biological behavior in NSCLC. Methods：The protein expression of VEGF and EGFR were detected in 112 NSCLC by immunohistochemistry streptavidin - perosidase（SP）methods. Results：The positive rate of VEGF and EGFR were 56. 3% and 69. 6% respectively. The expressions of VEGF were significantly correlated with cigarette,histological grading,tumor mass,lymph node metastasis and clinical stage（P〈 0. 05）,while being independent with gender,age, tumor site and histological type（P 〉 0. 05）. EGFR expressions were related to age,histological type,histological grad-ing,tumor mass,lymph node metastasis and clinical stage（P 〈 0. 05）. No correlation was found between EGFR ex-pression and gender,cigarette,as well as tumor site（P 〉 0. 05）. Conclusion：Both of VEGF and EGFR play an im-portant role in the growth and metastasis of NSCLC and may be taking as independent prognostic indicators.