GnRH-a对子宫内膜非典型增生的治疗价值

The value of GnRH- a in treatment of endometrial atypical hyperplasia

目的:探讨GnRH-a在子宫内膜非典型增生(AEH)中的治疗价值。方法:将66例子宫内膜非典型增生患者按照随机的原则分为2组,A组患者(32例)使用GnRH-a(诺雷德)治疗,每月一次,连用6个月。B组患者(34例)使用孕激素(醋酸甲羟孕酮)连续治疗6个月。每3个月行宫腔镜检查,并行内膜活检,记录结果并进行统计学分析。结果:两组轻中度非典型性增生治疗效果,无统计学意义(P>0.05)。重度非典型增生治疗效果GnRH-a组低于孕激素组,P<0.05,有统计学意义。两组总的治疗效果比较,无统学意义(P>0.05)。结论:GnRH-a用于治疗子宫内膜非典型增生效果与醋酸甲羟孕酮相似,具有每月一次的方便性,但价格较贵。

Objective：To investigate the value of GnRH - a in the treatment of endometrial atypical hyperplasia （AEH）. Methods：All 66 cases of endometrial atypical hyperplasia patients were randomly divided into 2 groups. The patients in group A（32 cases）were treated with GnRH - a for 6 months. Patients in group B（34 cases）were treated with progesterone therapy for 6 months. Hysteroscopy examination and endometrial biopsy were applied every three months. Results：Among the patients with mild to moderate atypical hyperplasia,there was no statistical difference in the therapeutic effect between the two groups（P ＆gt; 0. 05）,while GnRH - a was not as effective as progesterone in the treatment of severe endometrial atypical hyperplasia（P 〈 0. 05）. There was no statistical difference between the thera-peutic effect of the two groups overall（P〉 0. 05）. Conclusion：The therapeutic effect of GnRH - a was similar to that of medroxyprogesterone acetate in the treatment of endometrial atypical hyperplasia.