电子结肠镜下4%甲醛溶液治疗宫颈癌放疗后放射性出血性直肠炎的疗效观察

Local formalin application for hem orrhagic radiation proctitis under electronic colonoscope

目的:放射性出血性直肠炎是盆腔恶性肿瘤放疗后的常见并发症,本研究旨在探索电子结肠镜下4%甲醛溶液治疗宫颈癌放疗后放射性出血性直肠炎的疗效。方法:选取我院于2012年5月至2014年5月确诊为宫颈癌并于接受放射治疗后出现放射性出血性直肠炎的患者104例,随机平均分为甲醛治疗组(52例)和对照组(52例),前组给予电子结肠镜下4%甲醛溶液局部治疗,后者给予思密达(3g)、地塞米松(5mg)和庆大霉素(8万单位)混合液保留灌肠治疗,比较该方法与传统方法治疗效果的差异。结果:甲醛组共治愈患者24例(46.2%),显效21例(40.4%),好转4例(7.7%),无效3例(5.7%),总有效率94.3%,未发现直肠溃疡和穿孔;对照组共治愈患者18例(34.6%),显效17例(32.7%),好转6例(11.5%),无效11例(21.2%),总有效率78.8%,甲醛组的疗效明显高于对照组(χ2=7.84,P<0.01)。结论:电子结肠镜下4%甲醛稀释液是治疗宫颈癌放射性出血性直肠炎的有效方法。

Objective：Hemorrhagic radiation proctitis is a complication that occurs in patients who receive radiation therapy for pelvic malignancies.This study was aimed to observe the therapeutic effect of 4% formaldehyde solution under electronic colonoscope.Methods：All 104 patients diagnosed with cervical cancer from May 2012 to May 2014 were selected.All the patients underwent hemorrhagic radiation proctitis after receiving radiation therapy.The patients were divided into two groups randomly,one was 4% formaldehyde group and the other was control group.Results：In formaldehyde group,24（46.2%） patients were cured,4（7.7%） patients were improved,3 patients had no effect,which accounted for 5.7% of all patients,the total effective rate was 94.3%.In control group,18（ 34.6%）patients were cured,6（11.5%） patients were improved,11 patients had no effect,which represented 21.2% of all patients,the total effective rate was 78.8%,the difference between study group and control group was statistically significant（ χ^2 7.84,P〈0.01）.Conclusion：Local treatment by 4% formaldehyde solution under electronic colonoscope is an effective method for radiation proctitis for cervical cancer patients.