沙美特罗替卡松治疗感染后咳嗽的临床观察

Efficacy of salmeterol and fluticasone propionate in the treatment of adults with postinfectious cough

目的探讨沙美特罗替卡松治疗感染后咳嗽的效果。方法以本院感染后咳嗽患者118例为研究对象,按照随机数字表法,将患者随机分为沙美特罗组(58例)和氯苯那敏组(60例),前者吸人沙美特罗替卡松(50μg沙美特罗,500μg替卡松),每次1吸,2次/日,后者口服氯苯那敏片,每次4mg,2次/日,疗程均为2周。观察治疗前后咳嗽症状的差异。结果吸入沙美特罗替卡松组患者和口服氯苯那敏组患者咳嗽症状都有明显改善,与治疗前比较差异有显著性,沙美特罗替卡松组治疗效果明显优于氯苯那敏组。结论吸入沙美特罗替卡松对感染后咳嗽有较好的治疗作用。

Objective To investigate the effectiveness of salmeterol and fluticasone propionate in the treatment of postinfectious cough. Method In this randomised and prospective study, 118 adults with postinfectious cough were recruited. According to the random number, patients were randomly assigned to salmeterol and fluticasone propionate group（58 cases） and chlorpheniramine group（60 cases） , the patients of salmeterol and fluticasone propionate group were treated by salmeterol and fluticasone propionate （50μg salmeterol, 500μg fluticasone）2 times every day for 2 weeks, the patients of chlorpheniramine group were took chlorpheniramine 4rag once time and 2 times every day for 2 weeks. Differences in cough symptoms of two groups were observed before and after treatment. Result In both groups, the cough symptoms were obviously improved than before treatment, there was significant difference than before treatment, the treatment of salmeterol and flutieasone propionate group is better than chlorpheniramine group. Conclusion Salmeterol and fluticasone propionate is an effective treatment for postinfectious cough.