急性高脂血症性胰腺炎与胆源性胰腺炎的临床特点对照研究

The Clinical Analysis of Cases With Hyperlipidemic Acute Pancreatitis and Biliary Pancreatitis

目的探讨高脂血症性胰腺炎(HLAP)与胆源性胰腺炎的临床差异。方法对63例HLAP患者(观察组)资料进行回顾性分析,并与42例胆源性胰腺炎患者(对照组)进行对照研究,对两组患者的体重指数(body mass index,BMI)、入院时48小时内的Ranson评分和CT严重指数(CTSI),入院后血淀粉酶(AMS)、血脂肪酶(LPS),白细胞(WBC)、天冬氨酸氨基转移酶(AST)、血糖(GLU)、血脂(TG、TC)、C反应蛋白(CRP)等数据进行比较分析。结果观察组发病年龄低于对照组,天冬氨酸氨基转移酶(AST),血淀粉酶(AMS)明显低于对照组,两组比较差异有统计学意义(P<0.05);观察组体重指数(BMI)、Ranson评分、CT严重指数(CTSI)、甘油三酯(TG)、总胆固醇(TC)、C反应蛋白(CRP)明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论高脂血症性胰腺炎临床特征有其特殊性,患者发病年龄低,形体肥胖,血脂增高明显,病情较重,易发展成重症。

Objective To explore the difference features between hyperlipidemic acute pancreatitis（HLAP） and biliary pancreatitis. Methods 63 patients diagnosed with HLAP were selected as experimental group; 42 cases of BAP were selected as the control group. All of those clinical data were retrospectively analyzed. Results The onset age of observation group, aspartate aminotransferase（AST）, serum amylase（AMS） was significantly lower than the control group, there were significant differences between two groups（P〈0.05）. The body mass index（BMI）, ranson score, CT severityindex（CTSI）, triglyceride（TG）, otal cholesterol（TC）, C reactive protein（CRP） of observation group were significantly higher than the control group. Conclusion The clinical feature of hyperlipidemic acute pancreatitis（HLAP） is different from acute pancreatitis of other etiologies, patients with HLAP are significantly younger and most of them are fatter than the control group and is much higher triglyceride and total cholesterol in HLAP patients. And more easily develop into severe pancreatitis.