普通肝素微量持续泵入对进展性脑梗死患者神经功能缺损程度的改善作用

The Effect of Trace Continued to Pump Into the Unfractionated Heparin on Progressive Cerebral Infarction Patients With Neurological Deficits

目的探讨普通肝素微量持续泵入对进展性脑梗死患者神经功能缺损程度的改善作用。方法将176例性进展性脑梗死患随机分为三组。A组采用普通肝素持续24 h静脉泵入;B组每天采用普通肝12 500U静脉滴注一次;C组每天采用低分子肝素钙5 000 U进行两次皮下注射。半月后对各组患者神经功能缺损程度及出血事件进行观察和对比。结果 A组总有效率最高,复发率最低,与B组、C组差异具统计学意义(P<0.05)。A组出血事件发生率比B组、C组高,但三组差异均无统计学意义(P>0.05)。结论普通肝素微量持续泵入能促使进展性脑梗死患者神经功能缺损程度得到显著减轻,且复发率较低。

Objective To investigate the continuous infusion of unfractionated heparin trace progressive improvement of functional defect in patients with cerebral infarction nerves. Methods 176 cases of progressive cerebral infarction patients were randomly divided into threegroups. A group with unfractionated heparin 24 h continuous intravenous infusion; group B common hepatic 12 500 U intravenously once a day, C group with daily low molecular weight heparin subcutaneously twice 5 000 U. After half of the patients in each group and the degree of neurological deficit bleeding events were observed and compared. Results A group was the most efficient, lowest recurrence rate, and group B, group C with a statistically significant difference（P〈0.05）. A group of bleeding event rate than group B, group C is high, but the three groups showed no significant difference（P〉0.05）. Conclusion The continuous infusion of unfractionated heparin can induce micro-progressive neurological functional defect in patients with cerebral infarction has been significantly reduced, and low recurrence rate.