ε-己内酯生产工艺研究进展

Research progress in process technology of ε-caprolactone

概述了ε-己内酯生产的2种工艺路线——环己酮和非环己酮路线。以环己酮为起始原料的工艺路线包括过氧酸氧化法、双氧水氧化法和氧气/空气氧化法等;非环己酮工艺路线包括己二酸酯化加氢法、1,6-己二醇催化脱氢法和6-羟基己酸缩合法。综合比较,有机过氧乙酸法是目前经济成本最具有竞争力的工艺,而符合我国国情的工业化工艺路线为双氧水间接制备过氧酸的路线,采用双氧水和醋酸酐或者双氧水和丙酸制备过氧酸,过氧酸再将环己酮氧化为ε-己内酯。

Two industrial production processes of ε-caprolactone, cyclohexanone process and non-cyclohexanone process,are introduced. ε-Caprolactone is typically produced by the oxidation of cyclohexanone using various oxidizing agents, such as percarboxylic acid, H2O2 or O2/air. Other processes for producing ε-caprolactone are also described, such as dehydrogenation of 1, 6-hexanediol process, esterification and hydrogenation of adipic acid process, and ε- hydroxycaproic acid cyclization process. The most economical process is oxidation of cyclohexanone using peracetic acid. However, H2O2 indirect oxidation methods are the logical choice that accords with Chinese national condition. It involves the production of peracetic acid by the reaction between hydrogen peroxide and acetic anhydride or propionic acid, which is then followed by the conversion of cyclohexanone to ε-caprolactone.