浓缩硼-10模拟移动床色谱分离的放大研究

Scale up of simulated moving bed chromatography separation of enriched boron-10

为实现SMB色谱分离硼-10的工业化,进行氯型硼特效树脂排代色谱法富集硼-10的SMB放大实验研究.放大研究中色谱柱的内径由原来的φ1.0 cm放大到φ8.5 cm,树脂也由原先的均匀小颗粒（平均为230 μm）改为商用粒度范围颗粒（平均为780 μm）.SMB放大色谱分离系统连续运行了约60 d（129次端口切换）,取得富集度31.11％ ～40.31％的硼-10酸固体68 g.根据Fujii理论公式,对SMB放大分离系统中不同端口切换次数时的富集因子ε和理论踏板高度HETP进行计算,结果发现ε和HETP在整个实验过程中均保持常量,其值分别为ε=0.0092±0.0007,HETP =0.83±0.10 cm.与前期小型SMB分离系统的实验结果相比,ε变小,HETP变大,分离效果变差明显.

In order to implement the industrial-scale simulated moving bed （SMB） chromatographic separation of enriched boron-10, a scale-up SMB test of boron-10 separation by displacement chromatography using a boron-specific resin XSC-700 in fluoride-form is carried out based on the previous work. The inner diameter of chromatographic column is enlarged from 10 mm to 85 ram, and the size of resin particle from 230 μm to 780 μm （ commercial resin）. The scale- up SMB test is run continuously for 60 days （129 port-switches） and the amount of enriched boric-10 acid solid for 31.11% -40. 31% （B-10 atomic fraction） is 68 g. The enrichment factor 8 and the height equivalent to a theoretical plate （HETP） are calculated for the scale-up SMB system at various number of port-switch based on Fujii＇s equation. The values of ε and HETP are found to be constant, 6 = 0. 009 2± 0. 000 7, HETP = 0. 83 ± 0. 10 cm, respectively. Compared with the experimental results from the previous small-scale SMB separation system, the separation results are much less effective due to smaller ε value and bigger HETP.