羧甲基纤维素生产中氯乙酸钠羟基乙酸钠测定方法的研究

Determination method of sodium chloroacetate hydroxyacetic acid sodium in production of carboxymethyl cellulose

羧甲基纤维素(CMC)生产过程中,氯乙酸钠为主要原料,羟基乙酸钠为主要副产物。利用高效液相色谱法检测CMC生产过程中醚化剂中氯乙酸钠和羟基乙酸钠含量的方法。采用Rspak KC-811色谱柱分离,在紫外440 nm检测,内标法定量,以柠檬酸为内标物。此方法操作简单、快速,结果准确可靠,对CMC生产过程中氯乙酸利用率的研究和提高提供有力保障。

In the process of producing the carboxymethyl cellulose （ CMC）, sodium chloroacetate is the main raw material and sodium hydroxy acetic acid is the main byproduct. High performance liquid chromatography （ HPLC ） method which is used to detect sodium chloroacetate and glycolic acid sodium in the etherifying agent is introduced. The detection is carried out using the Rspak KC -811 chromatographic column. The determination wavelength is at 440 nm by ultraviolet detector. Internal standard method with citric acid as internal standard is used for quantitative analysis. This method is simple, rapid, accurate and reliable and can provide powerful guarantee to improve the utilization rate of chloroacetic acid.