壳聚糖抑菌活性的研究进展

Progress of Antibacterial Activity of Chitsan

壳聚糖广泛存在于甲壳类动物、昆虫类、软体动物的壳以及真菌的细胞壁中,在地球上含量极为丰富,是一种具有无毒性、生物可降解性、良好的生物相容性、伤口愈合性以及止血剂的天然聚合物。作为最有前景的可再生聚合物材料,壳聚糖受到越来越多的关注。从壳聚糖的分子量、质量分数、脱乙酰度(DD)、环境p H值、离子强度以及菌株本身,对壳聚糖抑菌活性的影响进行综述,并简要介绍壳聚糖的抑菌机理。

Chitosan widely exists in crustaceans,insects,mollusks shells and Fungal cell walls,its content is extremely rich on earth. It possesses nontoxic,biodegradable natural polymers,well biological compatibility,wound-healing and hemostatic agent. As the most promising renewable polymeric material,more and more researchers pay attention to it. This article reviews from the effects of molecular weight of chitsan,concentration,degree of deacetylation,the p H value of environment,ionic strength and the strain antibacterial activity of chitosan,preliminary introduced the antimicrobial mechanisms of chitosan.