预注苯磺顺阿曲库铵对舒芬太尼诱发咳嗽的影响

Effect of pre-treatment with intravenous cisatracurium besilate on sufentanyl-induced cough

目的评价麻醉诱导前静脉预注苯磺顺阿曲库铵对舒芬太尼诱发咳嗽(SFIC)的抑制效果。方法 200例气管插管全麻患者随机分为2组,每组各100例。对照组静脉注射0.9%Na Cl 1 m L,苯磺顺阿曲库铵预处理组注射苯磺顺阿曲库铵0.01 mg·kg-1。2组均于5 min后静脉注射舒芬太尼0.4μg·kg-1,注射时间2 s。记录2组患者咳嗽发生次数和时间,并根据咳嗽次数进行严重程度分级。分别于注射0.9%Na Cl或苯磺顺阿曲库铵时、注射舒芬太尼时及注射后1,2 min记录患者血压、心率、呼吸、脉搏血氧饱和度及药物不良反应。结果苯磺顺阿曲库铵预处理组SFIC的发生率(11.0%)明显低于对照组(35.0%)(P<0.05);舒芬太尼诱发中度和重度咳嗽4例次(占36.4%),明显少于对照组的25例次(占71.4%)(P<0.05)。2组咳嗽发生时间、血压及心率比较,差异无统计学意义。结论苯磺顺阿曲库铵预处理能有效降低SFIC的发生率和强度。

Objective To observe the effect of intravenous cisatracurium besilate pre- treatment on sufentanyl- induced cough（ SFIC）.Methods Two hundred patients scheduled for elective surgery were randomly divided into two groups. Patients in treatment group received intravenous cisatracurium besilate 0. 01 mg·kg^- 1and those in control group were given 0. 9% Na Cl 1 m L through the left median cubital veins. Five minutes later,the patients were injected with sufentanyl 0. 4 μg·kg- 1in two seconds. The timing and numbers of coughing were recorded and classified according to numbers. The data of blood pressure,heart rate,respiration,Sp O2 and adverse reactions of patients were recorded at the moment of injection of 0. 9% Na Cl or cisatracurium besilate,the injection of sufentanyl and one and two minutes after injections. Results The incidence of cough was 11. 0%（ 11 /100） in treatment group and 35%（ 35 /100） in control group（ P〈0. 05）. The incidence of moderate and severe cough was significantly higher in the control group（ 71. 4%,25 /35） than in treatment group（ 36. 4%,4 /11）（ P〈0. 05）. There was no significant difference between two groups on the timing of cough,blood pressure and heart rate. Conclusion Cisatracurium besilate pre- treatment can effectively reduce the incidence and severity of SFIC.