血小板活化因子在药源性严重过敏反应中的研究现状

Advance of platelet activating factor in drug-induced anaphylaxis

药源性严重过敏反应有难以预测、发作突然和致命性等特点,从而成为困扰临床药物使用的重要安全性因素。由于目前尚无严格的随机对照试验支持抢救药物的推荐,医生常根据临床经验用肾上腺素、抗组胺药和/或糖皮质激素应对突发的药源性严重过敏反应。血小板活化因子(PAF)信号通路可为研究药源性严重过敏反应提供崭新的视角。本文将就药源性严重过敏反应的临床和流行病学特点、PAF通路、抗PAF通路的药物等进行概述。

The acute unpredictably life- threatening characteristic of drug- induced anaphylaxis hinders the safe use of clinical medication. In the absence of rigid randomized controlled trials supporting the recommendations for the treatment of immediate onset, doctors often treat drug- induced anaphylaxis with epinephrine, antihistamines and / or glucocorticoids. The researches in platelet activating factor signaling pathway could provide a novel perspective for drug- induced anaphylaxis. This review will briefly introduce the clinical and epidemiological characteristics of drug- induced anaphylaxis,platelet activating factor pathway and drugs targeting at this pathway.