孕酮和PI3K/Akt信号通路在缺氧缺血性脑损伤中的研究现状

Advance of progesterone and the signal pathway of phosphatidylinositol 3-kinase/protein kinase B in hypoxic ischemic brian damage

磷酸肌醇-3羟激酶/蛋白激酶B(PI3K/Akt)是一种经典的抗凋亡、促存活信号传导通路,在脑梗死、帕金森病、癫痫等神经系统疾病中发挥调节作用。孕酮是一种脂溶性甾体激素,对创伤性脑损伤、卒中、阿尔茨海默病等患者的神经保护有重要作用,其与p-Akt上调有关。本文通过收集讨论新生儿缺氧缺血性脑病(HIE)、孕酮和PI3K/Akt的研究报道,以期为进一步探讨孕酮在HIE中的神经保护作用与PI3K/Akt信号通路的关系提供一定的理论依据。

Phosphatidylinositol 3- kinase / protein kinase B（ PI3 K /Akt） is a classic anti- apoptotic and pro- survival signaling pathway,which plays a role in the regulation of cerebral infarction,Parkinson＇s disease,epilepsy and other neurological diseases. Progesterone is one of the fat- soluble sex hormones,which has been proved to have neuro- protective effect on nerological disease,such as brain injury,stroke and Alzheimer＇s disease,and it＇ s relevant to the up- regulation of p- Akt.Studies about the advance of neonatal hypoxic ischemic encephalopathy（ HIE）,progesterone and PI3K/Akt were collected and reviewed,anticipating that it will provide theoretical basis for the further research of the relationship between progesterone and the signal pathway of PI3 K / Akt in HIE.