(Z)-2-(2-氨基噻唑-4-基)-2-三苯甲氧亚氨基乙酸的合成

Synthesis of( Z)-2-( 2-Aminothiazol-4-yl)-2-trityloxyiminoacetic Acid

以去甲氨噻肟酸乙酯为起始原料,经醚化、精制、水解反应制得标题化合物。标题化合物经核磁共振氢谱确证化学结构,总收率61.6%,纯度98.61%。该制备过程原料易得,操作简单,收率稳定,具有工业化的价值。

（ Z）-2-（ 2-Aminothiazol-4-yl）-2-trityloxyiminoacetic acid was prepared from ethyl（ Z）-2-（ 2-aminothiazol-4-yl）-2-hydroxyiminoacetate by etherification,purification and hydrolysis. The structure of the target compound was confirmed by1 HNMR.The total yield was 61. 6%,and purity was 98. 61%. This synthesis method with readily available starting materials and easily controllable operation and stable yield is worthy of the pilot manufacture.