基于基线等比增减法的养心草配伍酸枣仁安神药效的实验研究

Experimental Study of the Hypnotic Effect of the Compatibility of Sedum aizoon L. and Semen Ziziphus Spinosa by Increase-decrease Baseline Geometric Proportion Design Method

目的优选养心草与酸枣仁配伍安神作用的最佳配比。方法采用基线等比增减法拟定养心草与酸枣仁不同比例配伍,观察其对小鼠协同戊巴比妥钠睡眠实验的影响。结果与空白组相比,处方3,4能显著延长小鼠的睡眠时间和增加小鼠入睡率(P<0.01),且以处方3药效最佳。结论处方3为养心草配伍酸枣仁安神作用的最佳比例。

OBJECTIVE To study the optimal proportion of the compatibility of Sedum aizoon L. and Semen Ziziphus Spinosa on hypnotic effect. METHODS According to the increase-decrease baseline geometric proportion design method,different proportion compatibility of Sedum aizoon L. and Semen Ziziphus Spinosa were optimized through observing the pentobarbital-induced sleep in mice. RESULTS Compared with the control group,prescriptions 3,4 could extent the sleep time significantly and increased the sleep rate（ P 0. 01）,and the prescriptions 3was best. CONCLUSION Prescriptions 3 is the best proportion of the compatibility of Sedum aizoon L. and Semen Ziziphus Spinosa. on hypnotic effects.