臭灵丹抗甲1型流感病毒FM1株感染小鼠的药效学研究

Antiviral Activity of Laggera pterodonta Against Influenza A Virus Infection in Mice

【目的】观察臭灵丹抑制甲1型流感病毒FM1株感染的体内药效。【方法】采用小鼠流感病毒性肺炎模型,通过检测小鼠体质量变化和肺指数、肺组织病理变化确认药物的体内抗病毒药效。【结果】病毒对照组的肺指数较正常对照组显著升高(P<0.001),表明该模型复制成功;臭灵丹高、中、低剂量组均未能有效缓解流感病毒感染小鼠的体质量下降(P>0.05);臭灵丹高、中、低剂量组可显著降低流感病毒感染小鼠的肺指数(P<0.05)。小鼠肺组织病理检查结果显示:臭灵丹低剂量组可以缓解肺组织病理性炎症。【结论】臭灵丹对甲1型流感病毒FM1株感染小鼠的病毒性肺炎具有一定的抑制作用。

Objective To study the inhibitory effect of Laggera pterodonta（ DC.） Benth. against influenza A virus infection in mice. Methods Mice model of pneumonia was established after infection with influenza virus.The changes of body mass, lung index and lung pathology were observed to verify the in-vivo antiviral activity of Laggera pterodonta. Results The lung index of the virus control group was higher than that of the normal control group（P〈0.001）, indicating the successful establishment of influenza-virus-induced pneumonia model. High-,moderate-and low-dose Laggera pterodonta had no effect on counteracting the decrease of body mass of model mice（P〉0.05）, but had obvious effect on decreasing the lung index of the model mice（P〈0.05）. Moreover,low-dose Laggera pterodonta had an effect on relieving the pulmonary inflammation in the infected mice. Conclusion Laggera pterodonta exerts certain inhibitory effect on viral pneumonia mice induced by influenza A virus infection.