桃红清血片对大鼠的长期毒性研究

Chronic toxicity study of Taohong Qingxue Tablets in rats

目的考察桃红清血片对大鼠的长期毒性。方法 Wistar大鼠灌胃桃红清血片5.0和0.83 g·kg-1生药,每天1次,连续12周,逐日观察动物行为、外观,每周及停药后2周称体重1次,于停药后24 h和14 d各查每组10只大鼠血液学指标、血生化指标,并处死以测脏器系数,对主要脏器进行病理检查。结果桃红清血片高、低剂量组大鼠的外观体征、行为活动、体重、脏器、血液学和血液生化学指标与空白对照组比较,均无明显差异;病理学检查未见与药物毒性有关的明显病变,停药2周后也未见药物延迟性毒性反应。结论桃红清血片无明显的长期毒性,临床用量下是安全的。

objective To observe the chronic toxicity of Taohong Qingxue Tablets in rats. Methods Wistar rats were fed Taohong Qingxue Tablets at dose of 5. 0 and 0. 83 g·dg^-1 crude drug for 60 times and 10 times of clinical use daily dose,once a day,continuous administration of 6 months. observed daily animal behavior,appearance,weighed one time weedly and withdrawal two weeds;10 rats of each group were measured with Indexes of hematology and blood biochemistry of after stopping 24 h and 14 d;And sacrificed to measure organ coefficient of the major organs for pathological examination. Results The appearance,behavior,weights,the indexes of hematology and the organ coefficient of low-dose group were norma1. There were no significant difference observed between treeting groups and the controls in the blood biochemical in-dicators. No obvious pathological changes was found in major organ of autopsy animal. It was also no delayed toxicity 2 weeds after discontinuation of the drug. Conclusion Taohong Qingxue Tablets had no apparent chronic toxicity and was safe to use with clinical dosage.