10种抗室性心律失常药物的有效性、安全性与经济性分析

Efficacy,economy and safety analysis of 10 kinds of anti-ventricular arrhythmia drugs

目的评价10种抗室性心律失常药物的有效性、安全性与经济性,为选择抗室性心律失常药物治疗方案提供参考。方法通过文献检索,汇总了10种口服抗室性心律失常药有效性、安全性的信息;以各种药物每月平均药费范围上限为成本,有效率为效果,进行成本-效果分析;,寻找效果/成本比良好的品种,并对治疗方案不良反应进行比较。结果抗室性心律失常药总有效率是78.71%,药物不良反应总发生率为13.97%;普罗帕酮、胺碘酮、索他洛尔、美西律、阿替洛尔费用较低,月成本范围在40.5-87.6元之间。结论我们要鼓励使用基本药物和高效安全及低成本的药物。

objective To evaluate the efficacy,economy and safety of 10 dinds of anti-ventricular arrhythmia drugs and give reference for rational selection of anti-ventricular arrhythmia drugs. Methods By searching literatures,the infor-mation of efficacy and safety of 10 dinds of anti-ventricular arrhythmic drugs were collected;Tading the top limit of average expense monthly as cost,efficiency as effectiveness,the analysis of cost-effectiveness was performed,to compare the cost-effectiveness ratio,the adverse reactions were also compared. Results The total effective rate of anti-ventricular ar-rhythmia medicine was 78. 71%,drug adverse reaction rate was 13. 97%;The lower cost drugs were propafenone,amioda-rone,sotolol,mexiletine,atenolol,every month cost were 40. 5-87. 6. Conclusion We encourage to use basic drugs and high efficient,high safe and low cost drugs.