基于介电电泳的微流控细胞分离芯片的研究进展

Research Progress on Microfluidic Chip of Cell Separation Based on Dielectrophoresis

细胞分离技术是细胞分选和细胞种群纯化的重要手段,在生物、医学、农业、环境等许多领域都有重要的应用,是当前生化分析领域的国际研究热点。本文介绍了基于介电电泳的微流控细胞分离芯片的研究现状,阐述了介电电泳的工作原理,并依据细胞尺寸、电极形状、外加信号方式等影响细胞介电电泳的关键因素对不同类型的微流控细胞分离芯片进行了详细介绍,并对该技术的未来发展趋势做了展望。

Cell separation technology is an important means for cell sorting and cell-population purification. It is the current international research hot spot in biochemical analysis which has very important applications in many fields such as biology, medicine, agriculture and environment. This review introduces the development status of cell separation using microfluidic chip based on dielectrophoresis. It expounds the working principle of dielectrophoresis and the key factors such as cell size, electrode shape and signals that impacts the dielectrophoresis of cell separation on different types of microfluidic chip. Finally, it forecasts the future development trend of cell separation using microfluidic chip based on dielectrophoresis.