毛细支气管炎血清及肺泡灌洗液肺表面活性蛋白对比研究

Comparative study of serum capillary bronchitis and alveolar lavage SP

目的探讨毛细支气管炎患儿血清及肺泡灌洗液中肺表面活性蛋白(SP)变化。方法选取80例毛细支气管炎患儿为毛细支气管炎组,40例非感染性疾病患儿为对照组,检测血清、肺泡灌洗液中SP含量。结果 SP-A、SP-B、SP-C、SP-D血清中含量,毛细支气管炎组高于对照组(P<0.05),毛细支气管炎组肺泡灌洗液中含量高于血清(P<0.05),重症患儿血清及肺泡灌洗液中含量均高于轻症患儿(P<0.05),双侧病变高于单侧病变患儿(P<0.05);Spearman分析毛细支气管炎患儿血清与肺泡灌洗液中SP含量有正相关性(P<0.05)。结论毛细支气管炎患儿血清及肺泡灌洗液中SP-A、SP-B、SP-C、SP-D随着病情严重程度及累计肺段的增加,含量随之增高,肺泡灌洗液中含量高于血清。

Objective To study the change of Sp in serum of patients with capillary bronchitis and alveolar lavage. Methods 80 patients with capillary bronchitis were selected as the capillary bronchitis group,and 40 children with infectious diseases as the control group. The content of SP in alveolar lavage fluid and serum was detected.Results The levels of SP-A,SP-B,SP-C and SP-D in serum were higher in the capillary bronchitis group than in the control group（ P〈0. 05）,and they were higher in alveolar lavage fluid than in serum（ P〈0. 05）. The level of SP in serum and alveolar lavage was higher in severe children than in mild children（ P〈0. 05）. Conclusion The content of SP-A,SP-B,SP-C and SP-D increases along with the severity of capillary bronchitis,and it is higher in alveolar lavage fluid than in serum.