2型糖尿病肾病患者疾病相关危险因素分析

Analysis of related risk factors of Type-2 Diabetes Nephropathy

目的分析2型糖尿病肾病(T2DN)患者疾病相关危险因素,探讨其与T2DN发生、发展的相关性。方法将300例T2DM患者根据尿白蛋白排泄率(UAER)不同分为三组,即A组101例、B组105例和C组94例。观察各组间相关指标的变化情况,分析与疾病的相关性。结果三组患者在性别、年龄、体重指数(BMI)、空腹血糖(FBG)、餐后2 h血糖(2 h PG)方面比较差异均无统计学意义(P>0.05);B组与C组患者病程长于A组(P<0.05),Hb A1c高于A组(P<0.05);B组患者尿素氮(BUN)、SCr、尿酸(UA)和UMA指标均高于A组(P<0.05);C组患者BUN、SCr、UA和UMA指标均高于A组和B组(P<0.05)。Logistic回归分析显示,病程、Hb A1c、SCr、UA和UAER是T2DN的相关危险因素。结论病程、Hb A1c、SCr、UA与T2DN的发生、发展有密切关系,病程、Hb A1c、SCr、UA与UAER呈正相关性。

Objective To investigate the related risk factors of Type-2 Diabetes Nephropathy（ T2DN）. Methods Three hundred T2 DN patients were divided into three groups; group A（ n = 101）,group B（ n = 105） and group C（ n = 94） according to UAER of the patients and relevant index change was observed and relevant factors of the disease were analyzed. Results There was no difference of statistical significance in the gender,age,BMI,FBG and 2h PBG among the three groups（ P〉0. 05）,the courses of disease of group B and C were longer than that of group A（ P〈0. 05）,Hb A1 c was higher than that of group A（ P〈0. 05）,and BUN,SCr,UA and UMA of group C were higher than that of group A and B（ P〈0. 05）. As shown by non-conditional Logistic regression analysis,the course of disease,Hb A1 c,SCr,UA and UAER were the relevant risk factors of T2 DN. Conclusion The course of disease,Hb A1 c,SCr,and UA are closely related to the occurrence and development of T2 DN,and the course of disease,Hb A1 c,SCr,and UA are positively correlated with UAER.